Dr. Eugene Fine and I will described the problem as laid out in our campaign at Experiment.com. The campaign intends to follow Dr. Fine's pilot study of ten advanced cancer patients on ketogenic diets and the in vitro jobs that we are carrying out in parallel.We got good feedback and some good questions and we want to continue the scientific interaction and keep the community intact that has been started on the"lab notes" at Experiment.  We'll recapitulate some of the points made during the  campaign and you can"ask the investigators" in remarks.

"What makes you think ketone bodies can help?"

Most direct experimental studies, however, must be considered preliminary and it's reasonable to ask why we believed ketone bodies may help.

The evidence supporting carbohydrate restriction, or particularly ketogenic diets in cancer remains largely indirect and speculative. Our recent perspective  summarized a number of the relevant evolutionary and mechanistic variables: the fundamental theme rests with the role of this glucose-insulin axis in boosting growth and proliferation, the overriding characteristic of cancer sells. So it has been observed for some time that individuals with diabetes have greater risk of cancer. Epidemiological and other kinds of studies are generally consistent with the idea although distinct cancers are more or less closely connected with diabetes. Drugs employed as diabetes treatment, especially metformin, have been found to have beneficial effects in cancer as well. Metformin lowers the chance of developing cancer although the effects on mortality aren't clear cut. We made the situation, in our critical review that dietary carbohydrate restriction is the first line of treatment for type 2 diabetes and the ideal adjunct for pharmacology in type 1 diabetes.

The association between cancer and diabetes in conjunction with the advantages of carbohydrate restriction in diabetes comprise one big connection. In dietary strategies, however, it's total caloric reduction that has received the most attention and, in fact, experiments show that if implemented as stated, calorie restriction represents a reliable approach to prevention and treatment of cancer, particularly in animal models. It is unknown how much of the effect is because of de facto reduction in particular macronutrients but when tested, carbohydrate reduction as the way of reducing calories prove best. We cited a significant study by Tannenbaum. He discovered, in 1945 (!) That a carcinogen-induced sarcoma in mice was repressed by reduction in total calories but if  decreased by especially lowering the carbohydrate intake, there was an improved response.

Odd in that this appears in complex scientific papers where the downstream effects of the stimulation may pinpoint twenty molecular elements and where the molecular targets of the"nutrients" are characterized and may specifically be the insulin receptor and the related IGF-1 (insulin-like growth factor -1) receptor. (Insulin is most likely important in that it stimulates IGF-1 activity by lowering the degree of the associated binding proteins). In such studies, where total caloric reduction is the independent variable, the participation of insulin and the insulin-dependent downstream pathways are shown to be involved.

It is now appreciated that the Warburg effect, the apparent reliance of tumors on glucose for fuel, is a key observation that has been insufficiently explored. The effect offers motivation and clues for investigating the metabolic approach to cancer. Warburg believed that all cancers showed this phenotype which is not true but a large number do; of significance is that one that doesn't, prostate cancer, is the outlier in the figure above on relation to diabetes. 

You’ll thank me for this Keto Philly Cheesesteak Stuffed Peppers recipe, I swear you will because it’s hard to make stuffed peppers .

I think many would say that the best part of any beef sub is the steak smothered in hot, melted cheese. Who needs the bread anyway? And I’m not gont gross it up with cauliflower rice either. A craving for the real thing, deserves the real thing!

I love meals that may be prepared beforehand, and these Keto Philly Cheesesteak Stuffed Peppers are an ideal dish to make ahead to portion out for low carb lunches or a quick dinner.  If you love the meat and only nibble on the pepper, then these Keto Philly Cheesesteaks are just 1 net carb each!

Servings: 4

Nutritional Facts: 1g Net Carbs| 399 Calories | 32g Fat | 3g Carbs | 20g Protein | 2g Fiber

*Note: If you opt to eat the whole green pepper shell, make certain to factor in the 4g extra net carbs per green pepper. These figures are for the filling just.

Ingredients:

• 4 green peppers
• 1 tbsp butter
• 1/4 cup chopped onions
• 1 tsp minced garlic
• 1/4 cup green peppers (comes from the top of the peppers you'll cut off)
• 1 pound shaved beef steak
• Montreal steak seasoning (or add your own salt/pepper seasoning)
• 2 tbsp mayonnaise
• 7 slices of pepper jack cheese

Measures:

1. Cut the tops off the green peppers and put them in the oven at 400 degrees F.
   
2. Add onions, green peppers (chopped from the tops of the green peppers you just cut), garlic and butter into a frying pan on medium. Cook until they're soft.
   
3. Add shaved steak to the pan and shake some Montreal beef (or other seasonings) on top. Cook all of the way through, chopping up with your spatula as you go.
4. Take the green peppers from the oven when they're soft, but not too soft to stuff. There should be some juice in the bottom, do not dump it!
5. Add a slice of cheese into the cooked steak in the skillet, and mix until melted. Turn burner off and take the pan off the burner.
6. Rip two slices of cheese in half and add a half on the bottom of every green pepper.
7. Add two tablespoons (could use less, this just makes it less dry) of mayonnaise to the steak and mix.
   
8. Spoon the meat into the green pepper shells.
   
9. Add a bit of cheese to the top of all of the stuffed peppers.
   
10. Put back in the oven on broil for approximately five minutes or until the cheese is melted to your own liking.
    
11. Enjoy!

In the event that you loved my Keto Philly Cheesesteak Stuffed Peppers, make sure you check out my article 15 Low Carb and Keto Sandwiches.

The post Keto Philly Cheesesteak Stuffed Peppers appeared first on WickedStuffed Keto Recipes Blog.