Ketogenic Diets for Cancer. I. “What makes you think that ketone bodies will help?”

Dr. Eugene Fine and I will described the problem as laid out in our campaign at Experiment.com. The campaign intends to follow Dr. Fine's pilot study of ten advanced cancer patients on ketogenic diets and the in vitro jobs that we are carrying out in parallel.We got good feedback and some good questions and we want to continue the scientific interaction and keep the community intact that has been started on the"lab notes" at Experiment.  We'll recapitulate some of the points made during the  campaign and you can"ask the investigators" in remarks.

"What makes you think ketone bodies can help?"

Most direct experimental studies, however, must be considered preliminary and it's reasonable to ask why we believed ketone bodies may help.

The evidence supporting carbohydrate restriction, or particularly ketogenic diets in cancer remains largely indirect and speculative. Our recent perspective  summarized a number of the relevant evolutionary and mechanistic variables: the fundamental theme rests with the role of this glucose-insulin axis in boosting growth and proliferation, the overriding characteristic of cancer sells. So it has been observed for some time that individuals with diabetes have greater risk of cancer. Epidemiological and other kinds of studies are generally consistent with the idea although distinct cancers are more or less closely connected with diabetes. Drugs employed as diabetes treatment, especially metformin, have been found to have beneficial effects in cancer as well. Metformin lowers the chance of developing cancer although the effects on mortality aren't clear cut. We made the situation, in our critical review that dietary carbohydrate restriction is the first line of treatment for type 2 diabetes and the ideal adjunct for pharmacology in type 1 diabetes.

cancer-diabetes

The association between cancer and diabetes in conjunction with the advantages of carbohydrate restriction in diabetes comprise one big connection. In dietary strategies, however, it's total caloric reduction that has received the most attention and, in fact, experiments show that if implemented as stated, calorie restriction represents a reliable approach to prevention and treatment of cancer, particularly in animal models. It is unknown how much of the effect is because of de facto reduction in particular macronutrients but when tested, carbohydrate reduction as the way of reducing calories prove best. We cited a significant study by Tannenbaum. He discovered, in 1945 (!) That a carcinogen-induced sarcoma in mice was repressed by reduction in total calories but if  decreased by especially lowering the carbohydrate intake, there was an improved response.

tannenbaum_low-carb_cr

Odd in that this appears in complex scientific papers where the downstream effects of the stimulation may pinpoint twenty molecular elements and where the molecular targets of the"nutrients" are characterized and may specifically be the insulin receptor and the related IGF-1 (insulin-like growth factor -1) receptor. (Insulin is most likely important in that it stimulates IGF-1 activity by lowering the degree of the associated binding proteins). In such studies, where total caloric reduction is the independent variable, the participation of insulin and the insulin-dependent downstream pathways are shown to be involved.

It is now appreciated that the Warburg effect, the apparent reliance of tumors on glucose for fuel, is a key observation that has been insufficiently explored. The effect offers motivation and clues for investigating the metabolic approach to cancer. Warburg believed that all cancers showed this phenotype which is not true but a large number do; of significance is that one that doesn't, prostate cancer, is the outlier in the figure above on relation to diabetes. 

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#103: Is A Plant Based Keto Diet Healthy — Dr. Will Cole

In our one hundred and third episode we talk to Dr. Will Cole about plant based keto diets. We delve a bit into ancestral health and chat about what makes a plant established keto diet superior in some ways to a carnivore diet. Take a listen!   SPONSORS: Pili Hunters Pili Nuts Code: Ketoconnect for […]

The article #103: Is A Plant Based Keto Diet Healthy — Dr. Will Cole appeared first on KetoConnect.

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The $12M NuSI/Ludwig Study ~ Part III: Some "Early" Lessons





Continuing on with discussion of:
Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial

In Part I, I discussed some problems with methodology, largely focusing on the reduced Run-In Phase that probably compromised the outcomes irreparably.

In Part II, I highlighted a critical issue with the Run-In Phase, the purpose of which was to produce a somewhat homogeneous"reduced weight state" to test various diets in maintenance of that state.

Finally, since randomization to the various test diets occurred after weight loss (PWL) randomization to maintenance evaluation diet wouldn't influence the impact of various BSL (pre-weight reduction baseline) steps on the Run-In outcome -- target = 12% ± 2 percent weight loss -- on a standard composition diet for all:  45% Carb / 30% Fat / 25% Protein.

The researchers seem to have made minimal adjustments, if any, during the Run-In Weight Loss so as to produce a more uniform outcome.  Rather, the result was a wide range of weight loss (5.6 to 16.0%, approximately 10.5percent ± 5%). 

Thus we've got an"accidental" test-within-a-test of this CIH/TWICHOO from these"early" results.

In the end, I provide these scatter plots for all 105 subjects who successfully completed the study, for whom complete data for insulin steps and energy expenditure were available at all time points.


The Carb-Insulin Hypothesis (aka TWICHOO) forecasts that weight loss will vary inversely with insulin levels:  The greater the insulin levels, the lesser the weight loss.  The Run-In Stage data supports no such connection (indeed, if anything, absolute weight loss was greater for those with higher baseline insulin measures.

Meanwhile, differences in weight loss can easily be explained by variation in caloric deficit throughout the calorie restricted Run-In due to rough estimation of baseline energy expenditure (vs. rigorous measure).

This post expands on some relationships of baseline (BSL) and post-weight reduction (PWL) measures as observed during the weight loss portion of the Run-In Phase.

Bottom Line:  Baseline insulin status seems to be irrelevant to weight loss on a"high carb" calorie-restricted diet.  



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Fat Boost Smoothie with Coconut Chantilly Cream

I need a boost that is fat most days. ?

Avocado is one of the most healthy low carb foods you can have. Low in carbohydrates, high in healthy fats, and packed full of nutrients, dare I say it is crucial for a low fat keto diet. It's smooth and buttery and used as a fruit in Asian nations. As a result, it's incorporated in a lot of ice cream sweet desserts, and smoothies! Coconut cream makes the shake more decadent and has a high fat content.

Fat Boost Smoothie with Coconut Chantilly Cream

This is great as a dessert when you need something sweet as you binge-watch your show, or after dinner. There's some prep time. Use a bowl for mixing the chantilly coconut lotion, preferably stainless steel. You could also replace another sugar replacement for allulose.

With whipped coconut cream and some grilled coconut cubes, we ’ ve topped this in the pictures.

Yields 4 portions of Fat Boost Smoothie with Coconut Chantilly Cream.

The Preparation

  • 1 moderate avocado, halved
  • 14 ounce can coconut milk
  • 2 1/2 tablespoons allulose
  • 2 ounces water
  • 8 oz ice cubes
  • 1/4 tbsp vanilla bean paste

The Execution

1. If the can of coconut milk has separated, whisk together until fully incorporated.

Fat Boost Smoothie with Coconut Chantilly Cream
2. In a blender, add vanilla bean paste , coconut milk, allulose, water, ice cubes, and the halves.

Fat Boost Smoothie with Coconut Chantilly Cream
3. Blend until thick and smooth.

4. To serve, pour to a glass.  You may top with coconut cream if you like.

Fat Boost Smoothie with Coconut Chantilly Cream

This makes a total of 4 servings of Fat Boost Smoothie with Coconut Chantilly Cream. Each serving comes out to be 252.75 Calories, 26.25g Fats, 3.7g Net Carbs, and 2.68g Protein.

Fat Boost Smoothie Calories Fats(g) Carbs(g) Fiber(g) Net Carbs(g) Protein(g)
1 medium avocado 227 21 12 9.2 2.8 2.7
14 oz.

The Preparation

  • 1 medium avocado, halved
  • 14 ounce can coconut milk
  • two 1/2 tablespoons allulose
  • 2 ounces water
  • 8 oz ice cubes
  • 1/4 tbsp vanilla bean paste

The Execution

  1. If the can of coconut milk has split, whisk together until fully incorporated.
  2. In a blender, add the avocado halves, coconut milk, allulose, water, ice cubes, and vanilla bean paste.
  3. Blend until smooth and thick.
  4. To serve, pour the avocado mixture into a glass.  If you would like you may top with coconut cream.
3.1
https://www.ruled.me/fat-boost-smoothie-with-coconut-chantilly-cream/

Roasted Rutabaga with Rosemary and Onions

Roasted rutabaga is a great lower carb potato substitute with an earthy sweetness and the faint peppery tang of radishes. Serve with roasted meats.

Roasted Rutabaga with rosemary and onions - a great low carb potato sub!

When you haven't tried rutabaga, I suggest you try this as your first recipe. It is so delicious my family could not stop eating it the other night. Who would have ever thought that my kids would eat rutabaga? Not me!

Ina Garten will tell you that everyone likes roasted vegetables. Roasting caramelizes the natural sugars in food, bringing out a wealthy and more concentrated flavor. And nothing could be easier than organizing seasoned vegetables in a pan and letting them do their thing in the oven.

Rutabagas are a root vegetable similar to turnips but a little firmer, sweeter, and with a lower water content. Both have an earthy flavor and a small radish-like tang or bite. When roasted, a rutabaga will feel more squash-like and keeps a firm texture while a turnip becomes more limp when roasted.

Cubed rutabaga and onions on a sheet pan.

I’m always on the lookout for low carb potato alternatives. The most common curry replacement is cauliflower. I use it to make loaded cauliflower, fluffy mashed cauliflower potatoes, and creamy cauliflower mac and cheese casserole. But, I really LOVE rutabaga. Yes, it’s high in carbohydrates, but if paired with grilled or roasted meats along with a salad, it’s nice for a ketogenic low carb diet.

I found that roasting the rutabaga with onions imparts a small sweetness and smokiness. Rosemary lends a pine-like pungency that's a great foil for the sweet earthiness of rutabagas. And as they roast, the rutabagas deepen in colour changing from light orange to a deep golden orange color. Roasted rutabaga cubes and onion on a sheet pan.

While we enjoyed the roasted rutabaga right out of the oven, I found that completing the in a frying pan deepens the flavor even further. Who would have thought that 4 simple components also salt and pepper could taste so good?

Roasted rutabaga is the perfect accompaniment for rich meaty dishes. We loved it using Mississippi roast and with lamb chops with mint sauce.

Roasted rutabaga is a great lower carb potato substitute with an earthy sweetness along with the faint peppery tang of radishes.

  • 1 pound Rutabaga, peeled and cut into 3/4-inch cubes
  • 1/4 cup Diced onion ((1 oz))
  • 1 tbsp Chopped fresh rosemary
  • 1 tablespoon Olive oil
  • 1/4 tsp Salt
  • 1/8 tsp Freshly ground pepper
  • 1 tbsp Butter or ghee
  1. Preheat oven to 400 F and place rack in middle position. Line a sheet pan with parchment paper.

  2. Toss cubed rutabaga with onion, olive oil, salt, and pepper and spread onto the sheet pan in an even layer.  Bake for 20-30 minutes or until fork tender.

  3. Heat a medium-large frying pan over medium heat. When hot, add the butter and swirl to coat the pan. Fry the rutabaga until browned. 

  4. Serve with grilled, pan seared, or roasted meats and a side salad to minimize extra carbs.

  5. Serves 4 at 7 g net carbs per servings.

Nutrition Facts
Rosemary Roasted Rutabaga
Amount Per Serving
Calories 100 Calories from Fat 59
% Daily Value*
Total Fat 6.51g 10%
Cholesterol 8mg 3%
Sodium 24mg 1%
Total Carbohydrates 10g 3%
Dietary Fiber 3g 12 percent
Sugars 6.66g
Protein 1.47g 3%
* Percent Daily Values are based on a 2000 calorie diet.

lamb with mint sauce and roasted rutabagas with green salad

Lamb Chops with Mint Sauce

The post Roasted Rutabaga with Rosemary and Onions appeared first on Low Carb Maven.

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