Ketogenic Diets for Cancer. I. “What makes you think that ketone bodies will help?”

Dr. Eugene Fine and I will described the problem as laid out in our campaign at Experiment.com. The campaign intends to follow Dr. Fine's pilot study of ten advanced cancer patients on ketogenic diets and the in vitro jobs that we are carrying out in parallel.We got good feedback and some good questions and we want to continue the scientific interaction and keep the community intact that has been started on the"lab notes" at Experiment.  We'll recapitulate some of the points made during the  campaign and you can"ask the investigators" in remarks.

"What makes you think ketone bodies can help?"

Most direct experimental studies, however, must be considered preliminary and it's reasonable to ask why we believed ketone bodies may help.

The evidence supporting carbohydrate restriction, or particularly ketogenic diets in cancer remains largely indirect and speculative. Our recent perspective  summarized a number of the relevant evolutionary and mechanistic variables: the fundamental theme rests with the role of this glucose-insulin axis in boosting growth and proliferation, the overriding characteristic of cancer sells. So it has been observed for some time that individuals with diabetes have greater risk of cancer. Epidemiological and other kinds of studies are generally consistent with the idea although distinct cancers are more or less closely connected with diabetes. Drugs employed as diabetes treatment, especially metformin, have been found to have beneficial effects in cancer as well. Metformin lowers the chance of developing cancer although the effects on mortality aren't clear cut. We made the situation, in our critical review that dietary carbohydrate restriction is the first line of treatment for type 2 diabetes and the ideal adjunct for pharmacology in type 1 diabetes.

cancer-diabetes

The association between cancer and diabetes in conjunction with the advantages of carbohydrate restriction in diabetes comprise one big connection. In dietary strategies, however, it's total caloric reduction that has received the most attention and, in fact, experiments show that if implemented as stated, calorie restriction represents a reliable approach to prevention and treatment of cancer, particularly in animal models. It is unknown how much of the effect is because of de facto reduction in particular macronutrients but when tested, carbohydrate reduction as the way of reducing calories prove best. We cited a significant study by Tannenbaum. He discovered, in 1945 (!) That a carcinogen-induced sarcoma in mice was repressed by reduction in total calories but if  decreased by especially lowering the carbohydrate intake, there was an improved response.

tannenbaum_low-carb_cr

Odd in that this appears in complex scientific papers where the downstream effects of the stimulation may pinpoint twenty molecular elements and where the molecular targets of the"nutrients" are characterized and may specifically be the insulin receptor and the related IGF-1 (insulin-like growth factor -1) receptor. (Insulin is most likely important in that it stimulates IGF-1 activity by lowering the degree of the associated binding proteins). In such studies, where total caloric reduction is the independent variable, the participation of insulin and the insulin-dependent downstream pathways are shown to be involved.

It is now appreciated that the Warburg effect, the apparent reliance of tumors on glucose for fuel, is a key observation that has been insufficiently explored. The effect offers motivation and clues for investigating the metabolic approach to cancer. Warburg believed that all cancers showed this phenotype which is not true but a large number do; of significance is that one that doesn't, prostate cancer, is the outlier in the figure above on relation to diabetes. 

Keto Philly Cheesesteak Stuffed Peppers

You’ll thank me for this Keto Philly Cheesesteak Stuffed Peppers recipe, I swear you will because it’s hard to make stuffed peppers .

I think many would say that the best part of any beef sub is the steak smothered in hot, melted cheese. Who needs the bread anyway? And I’m not gont gross it up with cauliflower rice either. A craving for the real thing, deserves the real thing!

I love meals that may be prepared beforehand, and these Keto Philly Cheesesteak Stuffed Peppers are an ideal dish to make ahead to portion out for low carb lunches or a quick dinner.  If you love the meat and only nibble on the pepper, then these Keto Philly Cheesesteaks are just 1 net carb each!

Servings: 4

 Cook Time: 15 minutes 

Nutritional Facts: 1g Net Carbs| 399 Calories | 32g Fat | 3g Carbs | 20g Protein | 2g Fiber

*Note: If you opt to eat the whole green pepper shell, make certain to factor in the 4g extra net carbs per green pepper. These figures are for the filling just.

Ingredients:

  • 4 green peppers
  • 1 tbsp butter
  • 1/4 cup chopped onions
  • 1 tsp minced garlic
  • 1/4 cup green peppers (comes from the top of the peppers you'll cut off)
  • 1 pound shaved beef steak
  • Montreal steak seasoning (or add your own salt/pepper seasoning)
  • 2 tbsp mayonnaise
  • 7 slices of pepper jack cheese

Measures:

  1. Cut the tops off the green peppers and put them in the oven at 400 degrees F.
    grain-free philly cheesesteak
  2. Add onions, green peppers (chopped from the tops of the green peppers you just cut), garlic and butter into a frying pan on medium. Cook until they're soft.
    grain-free philly cheesesteak
  3. Add shaved steak to the pan and shake some Montreal beef (or other seasonings) on top. Cook all of the way through, chopping up with your spatula as you go.
  4. Take the green peppers from the oven when they're soft, but not too soft to stuff. There should be some juice in the bottom, do not dump it!
  5. Add a slice of cheese into the cooked steak in the skillet, and mix until melted. Turn burner off and take the pan off the burner.
  6. Rip two slices of cheese in half and add a half on the bottom of every green pepper. grain-free philly cheesesteak
  7. Add two tablespoons (could use less, this just makes it less dry) of mayonnaise to the steak and mix.
    grain-free philly cheesesteak
  8. Spoon the meat into the green pepper shells.
    grain-free philly cheesesteak
  9. Add a bit of cheese to the top of all of the stuffed peppers.
    grain-free philly cheesesteak
  10. Put back in the oven on broil for approximately five minutes or until the cheese is melted to your own liking.
    grain-free philly cheesesteak
  11. Enjoy!

In the event that you loved my Keto Philly Cheesesteak Stuffed Peppers, make sure you check out my article 15 Low Carb and Keto Sandwiches.

The post Keto Philly Cheesesteak Stuffed Peppers appeared first on WickedStuffed Keto Recipes Blog.

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Easy Keto Rack of Lamb with Herbs and Garlic

If you're looking for an elegant meal to serve on a special occasion, I must mention that a roast rack of lamb will certainly impress your guests.

Yet it's one of the easiest meals to make!

Once you learn how easy it is to roast this crispy and succulent rack of lamb, a ‘special occasion’ will be whenever you see it on sale!

That’s precisely what happened recently when my neighborhood supermarket had lamb racks on a Buy one, Get one free promotion. I simply could not resist.

How perfect that lamb is zero carbohydrates and all we need is a few basic things to make this a tasty yet impressive low carb keto meal.

Want to know how healthy lamb is?


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What Herbs go well with Lamb?

My favorite way to create a lamb rack is with a marinade of olive oil, lemon, fresh rosemary, garlic  and thyme.

But honestly, I like lamb pretty much any way I’ve tried it!

  • Dijon, lemon, garlic and thyme
  • salt, pepper and garlic
  • parsley, rosemary and thyme
  • many people like mint with lamb.  Not me, but perhaps it’s for you!

What sides go nicely with rack of lamb when doing keto or low carb? Lamb and Asparagus Sheet Pan

  • There’s something about asparagus which makes me think I want lamb and vice versa!
  • Easter is the ideal time to make lamb because so many spring veggies are ready
  • Roast some  veggies right in the pan!  Think cherry tomatoes, asparagus, tender young zucchini and radishes.  It is easy to make this a one pan sheet pan dinner!
  •  Pure comfort food when you add pureed cauliflower (see my cauli mash recipe )
  • For guests, make a greek cauliflower rice dish with parsley, peppermint and lemon

With this recipe, I roasted asparagus right in the sheet pan with the lamb racks.  And I used lemon, rosemary, garlic, thyme and olive oil on the lamb.



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Recipe Card for Simple Roast Rack of Lamb with Garlic and Herbs

Yield: 8 servings

Easy Keto Rack of Lamb with Herbs and Garlic

Easy Keto Rack of Lamb with Herbs and Garlic
Juicy succulent roast rack of lamb is so ketogenic and so fancy! Yet it is fast and easy enough for a weeknight dinner. Perfect Easter meal.
Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes

Ingredients

  • two Lamb racks (about 6-8 ribs each)
  • 2 tbsp olive oil
  • juice of 1 lemon
  • 1 tbsp minced garlic (3-4 tsp )
  • 2 rosemary sprigs
  • 2 thyme sprigs
  • pepper and salt

Instructions

Planning:

  1. Put all the ingredients in a large ziploc bag
  2. Smoosh it about. Yes I believe that is a legit cooking term.
  3. Allow the lamb to marinate for a few hours or even overnight.

  1. Place ziploc bag on plate on the counter an hour before cooking to let it come to room temperature
  2. Preheat oven to 375
  3. Place lamb racks in skillet.
  4. Place rosemary sprigs in pan.
  5. If roasting veggies, organize them in the pan as well
  6. Check lamb with a thermometer at about 20-25 minutes. The lamb will be moderate at about 140 degrees
  7. Cook longer if needed to achieve desired temperature.
  8. Cover with foil and let rest for a couple of minutes.

Pin this juicy keto roast rack of lamb recipe to Pinterest:

Simple juicy and keto! Rack of Lamb is not just for Easter! Low Carb Sheet pan dinner.

The article Easy Keto Rack of Lamb with Herbs and Garlic appeared first on Ketogenic Woman.

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Paleo and Keto Fat Bomb Coconut Brownies (gluten free and dairy...

These Paleo and Keto Fat Bomb Coconut Brownies are made with a lot of awesome ingredients which support low carb dieters. The amazing people over at Keto the Great sent me these cool products to play around with so I made these scrumptious brownies for this sponsored post.

The major product that stands out for me is MCT oil powder  from a Keto the Great which is made of coconut oil. I enjoy it because it doesn’t have any additives or mystical ingredients. I like to mix it in my coffee when I need to get my day started with a few additional energy. MCT oil is extremely nourishing for the thyroid and is easily burned by the liver rather than stored on the body. I hope you love these Keto fat bomb brownies and leave a comment if you make them.

What's MCT powder? 

It is a MCT oil is superfood made from the saturated fatty acids made from coconut oil.  MCT oil is clear, odorless but then it is dried out to make a powder that is easy to use.

Health Benefits of MCT oil 

  • MCT raises ketones and ketones suppress the hunger hormone ghrelin
  • MCT raises the hormone cholecystokinin (CCK), which makes you feel satisfied after eating
  • MCT supports healthy gut bacteria
  • MCT helps boost energy for exercising
  • Eating MCT oil can help reduce appetite
  • Coconut based MCT helps raise body temperature and supports healthy thyroid function
  • Boosts mental clarity
  • Digests readily
  • Anti-inflammatoy

How to Use MCT Oil Powder

  • Add into a smoothie
  • Add to java for a creamy flavor
  • add to keto dessert
  • Use as a post or pre workout drink

Purchase here

Purchase here

I used this awesome coconut based MCT powder to add a little extra flavor to these fudgy chocolate brownies. I took them to a family gathering and everyone was asking for the recipe and second helpings. Be sure that you get some Keto the Great MCT powder in your recipes.

These Paleo and Keto Fat Bomb Coconut Brownies are extremely tasty, rich & decadent although they are gluten free and dairy free.

  • 3/4 cup cacao powder (organic one)
  • 2 eggs (organic and pastured is greatest )
  • 1/2 cup coconut oil (melted)
  • 1/2 cup Keto the Great MCT oil powder
  • 1/2 cup full fat coconut milk
  • 1 teaspoon vanilla extract
  • 1 cup almond flour (heaping (blanched is best))
  • 1/2 tsp baking soda
  • 1/2 cup shredded coconut
  • 1/2 cup walnuts (chopped)
  • 1/2 cup Swerve
  • 1/2 tsp stevia extract
  1. Preheat the oven to 350 degrees.
  2. In another bowl combine the almond flour, baking soda, shredded coconut.
  3. Mix the two bowls together and pour into a square 8×8  baking dish.

  4. Bake for half an hour and cool for 15 before serving.

    Makes 9 brownies.

    For a paleo version: sub 1/2 cup coconut sugar in place of Swerve.

Purchase here

Order here

keto brownies

Purchase here

Please pin it to share with others:


They have 3 great products so far that I have tried and enjoyed a lot. The MCT powder I used above in the brownie plus a great BHB drink that promotes ketosis in just a couple minutes. Also a multivitamin that can help us when our  personal diet isn’t enough to get all the nutrients we need.

We created Keto The Great because we believe being healthy should be more than just a diet but rather a glimpse into living a healthy lifestyle. And while a ketogenic lifestyle is a rewarding one, it can be tough to transition into. For many, getting to a place where you feel full and satisfied can be challenging. So our staff created Keto The Great supplements to help make that transition easier!

So said Alexander the Great. Keto the Great pays homage to the relentless perseverance of our namesake by providing products that empower you. Our nutritional supplements, shakes, and keto treats support you in your journey to a better, healthier you. The road will surely have its challenges, but we are here as your ally along the way, giving you the tools you need to succeed. 

Try the other great products from Keto the Great: 

BHB Ketone supplement: This is a excellent product to improve your transition into being in a ketogenic state. It may be used when you are only beginning the Keto Diet for over the rough beginning often known as the keto flu. Another way is to use it before training to boost performance. I like to use it to increase concentration when I am trying to have a whole lot of work done. Simply mix in water and drink on the go. Some people use this these types of products to compensate for eating carby foods but I don’t believe you'll get results you're seeking with that method.

Purchase BHB beverage here:

Keto Multivitamin:

Even the late great Dr. Atkins advised low carb dieters to add in a lot supplements to fill in the holes which may be left when changing your diet. Another reason all of us might need to consider vitamin supplements is that the soils are degraded and don’t supply the same number of minerals and vitamins for plants that they used to. Meaning that by the time we eat the veggies or fruit it's not possible to get the same nutrition out of it compared with 50-100 years back. This vitamin has selenium and zinc, even iodine from kelp for thyroid health. Also it has alpha lipoid acid that supports cognitive function and even turmeric which helps with inflammation. I am excited that there's a vitamin so in touch with the needs of a keto dieter!

Purchase Multi-Vitamins here:

The article Paleo and Keto Fat Bomb Coconut Brownies (gluten free and dairy free) appeared first on Grass Fed Girl.

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Tangy Ranch Chicken Wings

This crispy oven recipe for Tangy Ranch Chicken Wings is as simple as it is delicious. After trying one, your family and friends will gobble them up!

Tangy Ranch Chicken Wings bake in the oven and are out-of-this-world tasty. #ranchchicken #chickenwings #lowcarb #keto

The quest for crispy baked chicken wings is real my friends. To me, there's nothing worse than a wings. I'm delighted to say that these wings are crispy and flavorful . And since the ranch seasoning is home made, these ranch chicken wings are great for low carb and keto diets!

The secret to crisp baked chicken wings is proper preparation and a secret ingredient. They taste weird and salty, although there are recipes that use this specific method. With a little playing around I attained wings that tasted great.

As with similar recipes, after cutting on the wings into hints, wings, and drumettes, dry the wings with paper towels. Make certain that you save the wing tips for chicken stock, I pop them in freezer.

Toss the wings in a bowl with a little olive oil, coating them completely – I used my hands. Then sprinkle one teaspoon of BAKING POWDER over the wings and toss.

Flow is promoted by placing the wings onto a rack fitted into a sheet pan that is rimmed. Baking at 375 F appeared to be the temperature for my oven. I baked for 40 minutes, turning them after 20 minutes. Broiling for a further 10 minutes crisp I wanted and provided the colour.

NOTE: The wings are not as crispy as wings that are fried, but they're more crispy than baking them conventionally. If you want crispy as fried wings, try Nagi's crispy oven baked chicken wings. Careful not to dry out them!

Tangy ranch chicken wings pieces in a basket.

To jazz up the wings, give them a quick spray with olive oil and toss with my Homemade Ranch Seasoning. While studying this recipe I tossed the wings in shop bought ranch seasoning before baking. Every time the cooking process destroyed the ranch flavor leaving the wings salty and bland.

I tried baking the wings first and pitching them with ranch. They tasted good and tangy, but were horribly salty. I was cool with the ingredients in ranch so I made my own seasoning.

My favorite version of those Tangy Ranch Chicken Wings was a consequence of baking the wings as outlined previously and tossing with my homemade ranch seasoning after baking. They were SUPER! I hope you like them.

This oven recipe for Tangy Ranch Chicken Wings is as simple as it is delicious. Family and your friends will gobble them up after trying one! Low carbohydrate and keto recipe.

Preheat oven to 375 F with rack in middle position.

  • Dry chicken wings with paper towels and place into a bowl.

  • Mix chicken wings with 2 tsp olive oil until I use my hands. Sprinkle with 1 teaspoon of baking powder and mix. Repeat.

  • Place chicken wings on a wire rack, skin-side-up, over a sheet pan that is large. Bake for 40 minutes turning the chicken over half way through. 

  • Remove from the oven and turn skin-side-up again. Put under the broiler for 5-10 minutes or until the chicken is crispy and golden brown on top and juicy underneath.

  • Remove the chicken to a bowl and spray lightly. Sprinkle 1 teaspoon of ranch and stir to coat. Repeat include 1/4 tsp of salt with the seasoning. Serve.

  • Serves 4 people with 5-6 wing bits each.   

    Homemade Indian Chicken Tikka Wings Recipe

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    The post Tangy Ranch Chicken Wings appeared first on Low Carb Maven.

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